[Intraosseous sarcoma with osteoid production and evidence of an EWSR1::SSX1 gene fusion].

Authors

Christine Bollwein, Sebastian Breden, Carolin Knebel, Klaus Wörtler, Katja Specht, Carolin Mogler

Published in

Pathologie (Heidelberg, Germany). Oct 28, 2026. Epub Oct 28, 2026.

Abstract

The WHO Classification of Bone and Soft Tissue Tumors comprises more than 170 defined tumor entities. Moreover, an increasing number of very rare mesenchymal neoplasms with distinct molecular alterations are being described. In the present case of an intraosseous tumor in a 34-year-old woman, RNA-based targeted panel sequencing identified an EWSR1::SSX1 fusion. Following interdisciplinary discussion, this led to the working diagnosis of synovial sarcoma and influenced treatment planning. This case highlights the diagnostic value of molecular sequencing in diagnostically challenging sarcomas.

PMID:
42955348
Bibliographic data and abstract were imported from PubMed on 30 Oct 2026.

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