Photoinduced Charge-Transfer Complex-Mediated Decarboxylative Phosphoniumation.

Authors

Hailong He, Jiajin Chen, Hongyao Wang, Wenlong He, Tao Zhou, Zihao Chen, Zhiyan Xue, Qilong Wu, Ziyi Xu, Shuyang Liu, Yunhe Jin

Published in

Organic letters. Volume 28. Issue 43. Pages 13538-13544. Oct 30, 2026.

Abstract

Phosphonium salts are valuable intermediates in organic synthesis, but their preparation often requires harsh conditions and specific carbon precursors. Herein, we report a photoinduced decarboxylative phosphoniumation of redox-active esters (RAEs) for the direct synthesis of alkyl and benzyl phosphonium salts. A photoresponsive ternary charge-transfer complex (CTC) formed from NaI, tertiary phosphines, and RAEs enables the reaction under transition-metal- and external-photocatalyst-free conditions. The method tolerates diverse benzyl and aliphatic RAEs and tertiary phosphines, including commercial phosphine ligand frameworks, and enables the late-stage phosphoniumation of complex carboxylic-acid-derived substrates.

PMID:
42960959
Bibliographic data and abstract were imported from PubMed on 30 Oct 2026.

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