Fluid-driven robotic micromanipulation for assembloid fabrication.

Authors

Yang Wu, Gang Huang, Songlin Zhuang, Xinghu Yu, Wenqi Jia, Zhitai Liu, Zhan Li, Mingsi Tong, Li Zhang, Huijun Gao

Published in

Science advances. Volume 12. Issue 44. Pages eaei8832. Oct 30, 2026. Epub Oct 30, 2026.

Abstract

The assembly of cellular spheroids into spatially organized assembloids represents a transformative paradigm for modeling complex biological systems. However, the lack of standardized fabrication strategies fundamentally limits the precision and reproducibility of these models, hindering their widespread application. Here, we present a robotic micromanipulation platform-Fluid-Driven Tweezer with Visual Servo Control (FDT-VSC). By integrating multidimensional visual perception with microfluidic control, our system enables the gentle and programmable assembly of diverse cellular spheroids. Leveraging this platform, we achieve the bottom-up construction of structurally defined, heterogeneous multicellular tissues, and the programmed orchestration of multilineage models that recapitulate the complex microenvironments of early organogenesis. Crucially, the system improves consistency during the scalable fabrication of tumor-stroma assembloids, supporting reliable drug screening. These results demonstrate that FDT-VSC advances assembloid-based applications across modular tissue engineering, developmental biology, and drug discovery.

PMID:
42962036
Bibliographic data and abstract were imported from PubMed on 31 Oct 2026.

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