Regioselective and Diastereodivergent Gold-Catalyzed Propargylation of Synergistically Activated Chromones.

Authors

Julio Álvarez-Valle, Sergio Fernández, Cecilia Merino-Robledillo, Ignacio Funes-Ardoiz, Diego Sampedro, Javier Santamaría

Published in

The Journal of organic chemistry. Nov 02, 2026. Epub Nov 02, 2026.

Abstract

In this work, we report the use of propargylsilanes in a gold-catalyzed regio and distereoselective propargylation of chromones synergistically activated by in situ generated TMS+, using a picolinate gold complex as catalyst. A diastereodivergence is observed compared with the analogous reaction using a phosphite ligand for the gold catalyst. Formation of the major diastereoisomer is supported by a density functional theory (DFT) computational analysis of the mechanistic pathway, indicating kinetic control of the reaction selectivity.

PMID:
42962145
Bibliographic data and abstract were imported from PubMed on 31 Oct 2026.

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