Tunable Polycaprolactone-Gelatin Methacryloyl Composites for Fused Deposition Modeling Musculoskeletal Scaffold Fabrication.

Authors

Anthony An-Fa Dahm Chen, Jiannan Li, Philip James DePond, Richard Sammy Muniz, Andrea Sofia Flores Perez, Adrian J Lew, Michael J Gardner, David G Mohler, William Joseph Maloney, Yunzhi Peter Yang

Published in

Journal of biomedical materials research. Part A. Volume 114. Issue 11.

Abstract

The global musculoskeletal burden continues to outpace standard of care transplantation efforts and existing tissue engineering solutions, necessitating further development of scalable biomaterials. In this study, we introduce a novel synthesis of polycaprolactone-gelatin methacryloyl (PCL-GelMA) composite filament, compatible with standard fused deposition modeling (FDM) 3D printers, for scalable and customizable scaffold fabrication. By incorporating 15% and 30% (w/w) GelMA into a PCL matrix, we achieved tunable modulation of surface roughness, hydrophilicity, and degradation kinetics. Mechanical testing revealed nonlinear dependencies between GelMA content and tensile properties, suggesting that variation in GelMA particle size and distribution leads to a concentration-dependent trade-off between stiffness and structural integrity. Human mesenchymal stem cells (hMSCs) cultured on printed scaffolds maintained viability and proliferative capacity. By mitigating solvent toxicity through upstream processing, physically integrating constituents into a unified bulk matrix, and leveraging the accessibility of FDM printing, this material platform enables scalable translation and further biomaterial exploration.

PMID:
42963128
Bibliographic data and abstract were imported from PubMed on 31 Oct 2026.

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