Authors
Masato Hamasaki, Kazuhiko Kotani, Yoshitaka Iwazu, Makoto Kuro-O
Published in
Journal of clinical medicine research. Volume 18. Issue 10. Pages 721-727. Epub Oct 23, 2026.
Abstract
Chronic kidney disease (CKD) is a major condition with a substantial sociomedical and economic burden. Klotho plays a role in renal protection via its antioxidant and anti-inflammatory properties. Proteinuria is an early indicator of CKD. Although experimental studies have demonstrated the biological effects of Klotho in CKD, its clinical relevance to proteinuria remains unclear.
The present study investigated the association between the A/T alleles of the Klotho gene rs650439 single-nucleotide polymorphism (SNP) and proteinuria in a general Japanese population. Clinical and genotyping data from a total of 916 community-dwelling participants (mean age = 63 years old) were analyzed.
Participants carrying the minor TT genotype accounted for 13.2% of the population. The prevalence of proteinuria was significantly higher in the TT group than in the AA + AT group (15.7% vs. 7.3%, P < 0.01). Logistic regression analysis showed that the TT genotype was significantly associated with proteinuria (crude odds ratio (OR) = 2.37, 95% confidence interval (CI) 1.35-4.14). This association remained significant after adjustment for age, sex, and cardiometabolic factors (adjusted OR = 2.07, 95% CI 1.14-3.77).
These findings suggest that the TT genotype of Klotho gene rs650439 SNP may serve as a genetic marker for early renal proteinuria. Further research is required to confirm the findings.
PMID:
42964217
Bibliographic data and abstract were imported from PubMed on 31 Oct 2026.
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