Spatial patterns of amyloid clearance after donanemab: A preliminary 12-month real-world amyloid PET study in Japanese patients with early Alzheimer's disease.

Authors

Yuki Kujuro, Marina Saito, Manami Maruko, Emi Qian, Hidefumi Koh, Hitoshi Katai, Hidenori Hattori

Published in

Alzheimer's & dementia (Amsterdam, Netherlands). Volume 18. Issue 4. Pages e70539. Epub Oct 30, 2026.

Abstract

The regional pattern of amyloid clearance during donanemab treatment in routine practice is poorly characterized.
We analyzed amyloid positron emission tomography (Centiloid, regional standardized uptake value ratio, visual reads) at baseline and 12 months in 18 donanemab-treated patients with early Alzheimer's disease.
Clearance was near-complete (removal 96%; 72% visually negative, i.e., full treatment-related amyloid clearance), although lower in the 2 early-onset (78%) than the 16 late-onset patients (98%). Higher baseline burden and older age predicted greater clearance (r = 0.88, P < .001; r = 0.60, P = .009, respectively). This held regionally (r = 0.82-0.91, all P < .001), with the posterior cingulate and precuneus clearing first. Clearance was independent of medial temporal atrophy and unrelated to 12-month cognitive change.
Donanemab cleared regional amyloid in proportion to its baseline distribution, with deposition-heavy regions clearing first and the temporal cortex retaining residual signal, independent of neurodegenerative stage and unrelated to short-term cognition.

PMID:
42966975
Bibliographic data and abstract were imported from PubMed on 01 Nov 2026.

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