Metal-organic framework-assisted signal amplification in electrochemiluminescent microRNA biosensing: Current advances and barriers to clinical implementation.

Authors

Jing Ren, Huihui Cui, Xiaolong Zhou, Xianshu Zhou, Yawen Zhu, Jin Wang

Published in

Talanta. Volume 314. Pages 130899. Oct 31, 2026. Epub Oct 31, 2026.

Abstract

The rapid expansion of electrochemiluminescence (ECL) biosensing has created growing demand for efficient signal amplification strategies capable of meeting the sensitivity requirements of microRNA analysis. Among the available functional materials, metal-organic frameworks (MOFs) have evolved from simple signal carriers into multifunctional platforms that integrate probe loading, catalytic enhancement, programmable nucleic acid reactions, and emerging CRISPR-assisted amplification within a single sensing architecture. This review provides a mechanism-oriented perspective on MOF-assisted signal amplification strategies, highlighting how different amplification mechanisms govern analytical performance and practical applicability. Beyond summarizing representative biosensing systems, the advantages, limitations, and suitable application scenarios of different amplification strategies are critically compared to establish guidelines for rational biosensor design. Finally, the remaining obstacles to clinical translation are discussed, together with future opportunities for developing robust, integrated, and clinically deployable MOF-based ECL biosensing platforms.

PMID:
42967396
Bibliographic data and abstract were imported from PubMed on 02 Nov 2026.

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