Evaluation of a chitosan-based wound healing gel on acute/hard-to-heal wounds: a single cohort non-comparative clinical pilot study.

Authors

Heather Hodgson, Mark G Rippon, Alan A Rogers, Sue Rice, Joy Tickle

Published in

Journal of wound care. Volume 35. Issue 11. Pages 981-990. Nov 02, 2026. Epub Nov 02, 2026.

Abstract

This study investigated the safety and real-world effectiveness of a chitosan-based wound healing gel on a variety of acute and hard-to-heal wounds.
In this single cohort non-comparative clinical pilot study, ChitoCare Medical Triketra (Primex ehf, Iceland), a chitosan-based wound healing gel intended for the treatment of acute and hard-to-heal wounds and other skin conditions, was assessed for its safety and effectiveness in the management of a variety of acute and hard-to-heal wounds across a four-week evaluation period.
A total of 97 patients with 131 wounds were enrolled in the study, and a total of 89 wounds were included in the final analysis. The median relative wound area reduction was 39.2% for all wounds. At the end of the evaluation period, 68.4% of all wounds had improved. Median wound area decreased from 2.0cm² to 0.75cm². Mean coverage of the wound bed for all wounds with devitalised tissue (necrosis and slough) at baseline was 39.4%, which reduced to 16.3% at the final visit. An improvement in pain severity experienced (i.e., a reduction in pain) was reported for 48.6% of wounds. A high level of satisfaction was reported by clinicians with the chitosan-based wound healing gel, and 97.1% of clinicians indicated that they would recommend it to other healthcare professionals.
The results of this study showed that the chitosan-based wound healing gel was associated with wound progression, improvements in the condition of the wound bed and periwound skin, and a reduction in pain. These improvements, as well as a favourable safety profile, provide real-world evidence supporting the use of this chitosan-based wound healing gel in the treatment of acute and hard-to-heal wounds.

PMID:
42970426
Bibliographic data and abstract were imported from PubMed on 03 Nov 2026.

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