High-dimensionality approaches to the understanding and therapeutic manipulation of autoimmunity.

Authors

Vasuki-Ranjani Chellamuthu, Yunqian Zhao, Salvatore Albani

Published in

NPJ autoimmunity. Volume 1. Issue 1. Pages 7. Epub Oct 31, 2026.

Abstract

Autoimmune disease may arise from disruptions in immune architecture rather than isolated molecular defects. High-dimensional immunology now reveals dynamic cellular states, regulatory circuits, and tissue-specific immune niches, but translation into therapy remains limited. We propose an Architecture-Anomaly-Target-Lead framework that contextualises therapeutic targets within immune organisation and complements Reset-Rebuild strategies. Together, these concepts provide a framework for developing and evaluating more sustained, tolerance-focused treatment approaches for autoimmune disease.

PMID:
42973447
Bibliographic data and abstract were imported from PubMed on 03 Nov 2026.

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