Engineering AP/Exo-Cas12 as an efficient toolbox for rice genome editing via integrated repair and exonuclease modules.

Authors

Nan Chai, Ruixiang Zhang, Guangzhou Li, Liying Su, Jun Wen, Shirui Huo, Xudong Yuan, Ruyue Chang, Xinglei Zheng, Zhiye Zheng, Taoli Liu, Dongchang Zeng, Qiupeng Lin, Yao-Guang Liu, Xianrong Xie, Jiantao Tan, Qinlong Zhu

Published in

Journal of integrative plant biology. Nov 03, 2026. Epub Nov 03, 2026.

Abstract

A modular apurinic/apyrimidinic (AP)/Exo-Cas12 toolbox integrates cell selection enrichment with AP-repair pathways or exonucleases for plant editing. It achieves efficient multiplex genome editing and easily detectable large DNA deletions in rice, providing a robust platform for multigene knockouts and crop improvement.

PMID:
42974960
Bibliographic data and abstract were imported from PubMed on 03 Nov 2026.

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