Direct light-free cysteine-to-boronoalanine conversion in peptides.

Authors

Jeongsu Lee, Tomoko Hoshi, Honami Matsumoto, Manaka Maeda, You Nonaka, Daiki Fukue, Hayato Sasamoto, Taishi Ichinose, Yui Hiranaka, Minjae Kim, Tatsusada Yoshida, Yasuchika Yamaguchi, Kohei Yamada

Published in

Chemical communications (Cambridge, England). Nov 03, 2026. Epub Nov 03, 2026.

Abstract

Direct cysteine-to-boronoalanine conversion in peptides is achieved using B₂cat₂ and TPPTS in aqueous DMF/phosphate buffer at room temperature without irradiation. The method tolerates diverse peptide sequences, including methionine-containing and terminal-cysteine peptides, with no detectable epimerization or modification of other tested side chains.

PMID:
42976324
Bibliographic data and abstract were imported from PubMed on 04 Nov 2026.

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