Authors
Beth A Habecker, Johanna M Montgomery
Published in
Trends in neurosciences. Nov 03, 2026. Epub Nov 03, 2026.
Abstract
Neural control of the heart adjusts cardiac output to the functional demands of the body in order to maintain homeostasis. Sensory afferents monitor blood pressure, metabolites, and other parameters, sending information to the brainstem that then alters the balance of stimulatory sympathetic and inhibitory parasympathetic transmission to the heart. 'Autonomic imbalance' between sympathetic and parasympathetic efferent transmission in the heart is a characteristic of cardiovascular and metabolic diseases that contributes to pathology. In this review, we discuss recent studies related to the peripheral components of the cardiac control circuit. We summarize data from induced pluripotent stem cells, small and large animal models, and human studies that reveal more complexity in peripheral components of this system than previously understood. We also discuss peripheral neuroplasticity in cardiovascular disease and the potential impact of neuromodulation therapies.
PMID:
42977603
Bibliographic data and abstract were imported from PubMed on 04 Nov 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 9
- Comments 0