Authors
Shirley Soon Lee Tiang, Hao Shu, Wen Ao Bong, Shi Hui Law, Brianna Brianna, Gu Jia Heng, Bey-Hing Goh, Lor Huai Chong, Beng Ti Tey, Neil R Cameron, Liang Ee Low
Published in
International journal of biological macromolecules. Pages 155136. Nov 03, 2026. Epub Nov 03, 2026.
Abstract
This study reports the development of β-cyclodextrin grafted magnetic nanocellulose (MCNF-β-CD) as a drug carrier aimed at enhancing the bioavailability of hydrophobic drugs through encapsulation within the hydrophobic cavities of β-cyclodextrin (β-CD), while improving therapeutic selectivity via the stimuli-responsive behavior of magnetic nanocellulose (MCNF). The nanocarrier was characterized using Fourier transform infrared (FTIR) spectroscopy, thermal analysis, zeta potential, contact angle analysis and field emission scanning electron microscopy (FE-SEM). FTIR spectra confirmed successful crosslinking through ester bond formation, while thermal analysis, zeta potential, contact angle and FE-SEM results further verified β-CD grafting onto MCNF. The β-CD content on MCNF under the optimized formulation was found comprising ≈35 wt% and 65 wt% of β-CD and MCNF, respectively. Importantly, the incorporation of β-CD did not compromise the dual stimuli responsiveness of MCNF, as evidenced by contact angle and magnetic analysis. Using curcumin (CUR) as the model anticancer bioactive, the MCNF-β-CD achieved a CUR loading efficiency of 53.33 ± 0.8% and exhibited sustained drug release governed by a non-Fickian transport mechanism involving both diffusion and matrix swelling. MTT assays further confirmed the biocompatibility of the nanocarrier, highlighting its potential as a biocompatible and stimuli-responsive drug vehicle platform for the effective loading of poorly soluble drugs.
PMID:
42977049
Bibliographic data and abstract were imported from PubMed on 04 Nov 2026.
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