Authors
Michael Q Dong, Tania Ahuja, Geno Merli, Rachel P Rosovsky, Beverley J Hunt, James M Horowitz, Frances Mae West
Published in
Clinics in chest medicine. Volume 47. Issue 4. Pages 747-757. Epub Sep 07, 2026.
Abstract
Pulmonary embolism is a life-threatening condition requiring prompt anticoagulation to prevent clot propagation and recurrence. Risk stratification guides therapy, with systemic thrombolysis reserved for high-risk patients and selected intermediate-high risk cases due to significant bleeding risk. Direct oral anticoagulants are preferred for most low and intermediate-low risk patients, while low-molecular-weight heparin and unfractionated heparin remain critical for higher- risk or procedurally complex cases. Emerging strategies including low-dose thrombolysis, catheter-directed therapies, and the future use of Factor XI inhibitors may improve safety without compromising efficacy. Management of bleeding complications necessitates rapid intervention, reversal when available, and coordinated multidisciplinary care.
PMID:
42977381
Bibliographic data and abstract were imported from PubMed on 04 Nov 2026.
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