Authors
Omar Sheikh, Jun Li, Robert Lookstein, Stavros Konstantinides
Published in
Clinics in chest medicine. Volume 47. Issue 4. Pages 731-745. Epub Sep 21, 2026.
Abstract
This article summarizes the evolution of pulmonary embolism therapy, from early heparin use and landmark thrombolysis trials to modern catheter-based therapies, including catheter-directed thrombolysis and mechanical thrombectomy. It reviews how advancements in medical and device therapies have shaped treatment selection while highlighting persistent evidence gaps. Across decades of trials, the primary challenge remains achieving balance between effective reperfusion with optimization of safety outcomes and clinical benefit.
PMID:
42977380
Bibliographic data and abstract were imported from PubMed on 04 Nov 2026.
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