[Methylphenidate-induced liver damage].

Authors

L Allary, T Santy, H Tandt

Published in

Tijdschrift voor psychiatrie. Volume 68. Issue 8. Pages 463-467.

Abstract

Drug-induced liver injury (DILI) is liver damage caused by medicines and accounts for approximately 15% of all cases of liver failure. Psychotropic drugs account for a significant proportion of the above group of medicines. The clinical presentation can range from an asymptomatic mild elevation of liver enzymes to severe hepatitis. We discuss the case of a 22-year-old patient who presented at a follow-up appointment at a psychiatric outpatient clinic with asymptomatic liver damage, one week after starting treatment with methylphenidate. A review of the literature shows that this rare side effect is caused by an idiosyncratic, dose-independent pathological mechanism in which the metabolism of methylphenidate plays a significant role. Blood tests at the start of treatment are recommended for early detection, particularly in high-risk patients.

PMID:
42978504
Bibliographic data and abstract were imported from PubMed on 04 Nov 2026.

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