Anterior Chamber Depth Changes: After Phacoemulsification in Eyes With Pseudoexfoliation Syndrome Versus Control Eyes: A Systematic Review and Meta-analysis.

Authors

Constantine D Angelidis, Marios Katsimpras, Anastasia Tsiogka, Petros Petrou, Stylianos A Kandarakis, Lida P Lalou, Dimitrios Spyropoulos, George D Kymionis, Ilias Georgalas

Published in

Journal of refractive surgery (Thorofare, N.J. : 1995). Volume 42. Issue 11. Pages e617-e624. Epub Nov 01, 2026.

Abstract

To quantitatively assess the change in anterior chamber depth (ACD) following phacoemulsification in eyes with pseudoexfoliation syndrome (PEX) versus controls. Predicting postoperative ACD, which corresponds to the effective lens position, is important for minimizing refractive error after cataract surgery.
The PubMed and Scopus libraries were searched for publications with a control group. The primary outcome of the study was the change in ACD following phacoemulsification. Secondary outcomes were preoperative ACD, postoperative ACD, axial length, and preoperative and postoperative intraocular pressure. The effect measures were weighted mean differences with 95% confidence intervals (CIs). The Newcastle-Ottawa Scale was used for quality assessment of the cohort studies. The protocol was registered at the Prospective Register for Systematic Reviews (registration number CRD420251120246).
Seven studies were included in this meta-analysis, in which 515 eyes were enrolled (232 eyes in the PEX group and 283 in the control group). Preoperative ACD was narrower in the PEX group than the control group (weighted mean difference [WMD] = -0.140; 95% CI = -0.214 to -0.066; P < .001). Postoperative ACD did not differ significantly between the PEX group and the control group (WMD = 0.100; 95% CI = -0.021 to 0.221; P = .107). There was a greater mean ACD difference in the PEX group than the control group (WMD = 0.252; 95% CI = 0.169 to 0.336; P < .001).
The change in ACD was greater in the PEX group, which may reflect underlying zonulopathy. This may result in a greater than expected postoperative ACD and consequently more posterior effective lens position, resulting in an unexpected refractive result.

PMID:
42992810
Bibliographic data and abstract were imported from PubMed on 06 Nov 2026.

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