¹⁸F-fluorodeoxyglucose PET/Computed Tomography in Fever of Unknown Origin: A Comprehensive Clinical Review.

Authors

Kowshik Vengadesan, Ankita Phulia, Anil Chauhan

Published in

PET clinics. Nov 06, 2026. Epub Nov 06, 2026.

Abstract

This article provides a thorough summary of the most recent research on [F]fluorodeoxyglucose PET/computed tomography (CT) in the assessment of fever and inflammation of undetermined origin (FUO/IUO). The pathophysiologic basis of FDG uptake in infection and inflammation, preparation for the scan, pooled diagnostic performances, characteristic uptake patterns for interpretation, its role in prognostication, cost-effectiveness, and imaging pitfalls are all covered. Additionally, a diagnostic approach that uses FDG PET/CT as a preliminary second-line test is suggested. Long axial field-of-view PET/CT, PET/MR imaging, and new pathogen-specific tracers are also highlighted as interesting future possibilities for enhancing diagnostic specificity in FUO/IUO.

PMID:
42995018
Bibliographic data and abstract were imported from PubMed on 07 Nov 2026.

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