Authors
Byron Ray Ayala Galarza, Erick David Vallejo Urquizo, Tamara Belén Yánez Villacrés, Kimberly Jamileth Velásquez Carrasco, Roxana Estefania Azogue Alban, Verónica Fernanda Altamirano Navas
Published in
Infectious diseases now. Pages 105382. Nov 07, 2026. Epub Nov 07, 2026.
Abstract
To assess whether higher circulating cell-free mitochondrial deoxyribonucleic acid concentrations within the first 24 h are associated with higher all-cause mortality at 28-30 days in adults with sepsis.
PubMed, Scopus, and Web of Science Core Collection were searched on October 17, 2026. Eligible observational studies will assess early circulating concentrations and prognosis. At least two reviewers will independently select studies, extract data, and assess risk of bias using Quality In Prognosis Studies or the Joanna Briggs Institute analytical cross-sectional tool. Certainty will be assessed using Grading of Recommendations Assessment, Development and Evaluation. Meta-analysis will require at least three independent studies with compatible estimates for the same outcome. Inverse-variance random-effects models will use restricted maximum likelihood and modified Hartung-Knapp intervals. Association measures, discrimination, and concentration differences will be synthesized separately. When a cohort reports both mortality horizons, 28-day estimates will be preferred; 30-day-only estimates will remain eligible.
The review will characterize associations with mortality and organ dysfunction, discrimination, and additional prognostic information, accounting for baseline severity, clinical setting, and measurement conditions.
The synthesis will inform further evaluation of this biomarker for risk assessment in sepsis.
PMID:
42998791
Bibliographic data and abstract were imported from PubMed on 08 Nov 2026.
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