The Association Between Oxidative Balance Score and All-Cause Mortality in Patients With Rheumatoid Arthritis.

Authors

Junfeng Jia, Guangzhi Xiao, Jinlin Miao, Yan Zheng, Jin Ding, Zhaohui Zheng

Published in

International journal of rheumatic diseases. Volume 29. Issue 11.

Abstract

This study aimed to explore the associations of the oxidative balance score (OBS) and all-cause and cardiovascular disease (CVD) mortality in patients with rheumatoid arthritis (RA), and to analyze the mediating role of the neutrophil-to-lymphocyte ratio (NLR).
Data were obtained from the National Health and Nutrition Examination Survey. Cox proportional hazards models were used to assess the associations of total OBS, dietary OBS, and lifestyle OBS with all-cause and CVD mortality. Restricted cubic spline (RCS) analysis was performed to explore dose-response relationships, while subgroup analysis was conducted to verify the robustness of the results. Mediation analysis examined NLR-mediated association between OBS and all-cause mortality.
887 RA patients were analyzed, with 79 deaths during follow-up. In the fully adjusted model, each 1-unit increase in total OBS, dietary OBS, and lifestyle OBS was associated with a 6%, 7%, and 25% lower risk of all-cause mortality, respectively. Total OBS was negatively associated with CVD mortality when analyzed as a continuous variable, but not when categorized into tertiles. RCS analysis confirmed linear dose-response relationships between total OBS, dietary OBS, lifestyle OBS, and all-cause mortality. NLR mediated a small proportion of the associations of total OBS (5.47%) and dietary OBS (4.89%) with all-cause mortality. Subgroup analysis showed that the negative association between total OBS and all-cause mortality across several subgroups.
Higher total OBS, dietary OBS, and lifestyle OBS were significantly associated with reduced all-cause mortality in RA patients, with a linear dose-response relationship.

PMID:
43000989
Bibliographic data and abstract were imported from PubMed on 09 Nov 2026.

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