Authors
Shanshan Yang, Yujie Ma, Yafeng Zhang
Published in
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. Volume 47. Issue 12. Nov 09, 2026. Epub Nov 09, 2026.
Abstract
This study aimed to explore the association between allostatic load (AL) and severe headache or migraine and to assess whether this association varies based on AL score criteria.
We analyzed nationally representative, cross-sectional data from the National Health and Nutrition Examination Survey (NHANES). The AL score was calculated using both empirical and clinical criteria based on eight biomarkers reflecting cardiovascular, metabolic, and immune function. Weighted multivariate logistic regression models were employed to examine the independent association between AL score and severe headache or migraine.
Among 2,391 participants, 475 (22%) reported severe headache or migraine. After adjusting for covariates, higher AL scores were significantly associated with increased odds of severe headache or migraine, a finding consistent across both scoring methods (empirical AL score: OR 1.14 [95% CI 1.05-1.24]; clinical AL score: OR 1.10 [95% CI 1.01-1.19]).
This study found that higher AL scores were significantly associated with higher odds of severe headache or migraine in the U.S. adult population, and this association was consistent across scoring methods. These findings highlight the potential relevance of cumulative multisystem physiological burden to research and health assessments related to severe headache or migraine.
PMID:
43000515
Bibliographic data and abstract were imported from PubMed on 09 Nov 2026.
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