Authors
Natalia G Vallianou, Gerasimos Socrates Christodoulatos, Apostolos A Evangelopoulos, Angelos Evangelopoulos, Maria Dalamaga, Dimitrios Chatzis, Nikos Mantouvalos, Dimitris Kounatidis
Published in
Infection. Nov 09, 2026. Epub Nov 09, 2026.
Abstract
Community-associated Clostridioides difficile infection (CA-CDI) has been defined as the presence of CDI on an outpatient basis or within 48 h of hospitalization in a patient not having been discharged from a healthcare facility during the previous 12 weeks. According to the Centers for Disease Control and Prevention (CDC), the prevalence of CA-CDI in 2023 has surpassed healthcare-associated CDI (HA-CDI). Based upon the alarmingly increasing rates of CA-CDI, there is an urgent need for preventive measures as well as improved and widely implemented surveillance systems in order to contain this spread. The purpose of this review is to elaborate upon the intricate interplay between humans, animals and the soil, as reservoirs of Clostridioides difficile. In this regard, the One Health Approach will shed light upon this complex interconnection. Finally, within this framework, the prudent administration of antimicrobial agents as well as the potential role of machine learning will be pointed out.
PMID:
43002359
Bibliographic data and abstract were imported from PubMed on 10 Nov 2026.
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