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Lipid II flipping in monoderms: structural insights from Staphylococcus aureus.

Created on 10 Nov 2026

Authors

Eric Cester, Camilo Perez

Published in

Trends in biochemical sciences. Nov 09, 2026. Epub Nov 09, 2026.

Abstract

Peptidoglycan synthesis in diderm and monoderm bacteria depends on lipid II flipping between membrane leaflets, but how this process occurs remains unclear. Li et al. report cryogenic electron microscopy structures of a lipid II flippase from the monoderm Staphylococcus aureus and provide a direct comparison with similar flippases from diderm bacteria.

PMID:
43003720
Bibliographic data and abstract were imported from PubMed on 10 Nov 2026.

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