Authors
Chien-Wei Lin, Tzu-Yu Pan, Jia-Jen Chen, Sih-Syuan Li, Ming-Wei Su, Ming-Tsang Wu
Published in
Nephrology (Carlton, Vic.). Volume 31. Issue 11.
Abstract
Rapid decline of kidney function increases the risk of morbidity and mortality, but few studies have conducted genome-wide association studies (GWAS) to examine the association with kidney function decline.
This study used over 110 000 Taiwanese adults with 28 426 follow-ups in a community-dwelling longitudinal cohort (Taiwan Biobank) to identify the important genetic loci of five kidney function-related traits, and to predict the rapid decline of kidney function.
A total of 68 genetic loci were significantly overlapped in any two of the five kidney-related traits (p = 5 × 10-8). A genetic correlation network of 68 genetic loci showed all five kidney function-related traits were closely related. BUN and creatinine in serum and eGFR were clustered to interconnect with bone density measurement and kidney stone, urine microalbumin was interconnected with hypertension and diabetes, and serum uric acid was positively correlated with serum lipid profiles and gout. Among the 68 significant genetic loci identified, six were significantly associated with kidney function decline among the 28 426 participants with follow-up data. Using a cohort of 266 early CKD patients (stage I-III) with an averaged ~6 years of follow-up prospectively, we further found the genetic locus of rs3925584, close to the MPPED2 gene, significantly predicted the slope of kidney function decline (p = 0.0193).
These findings provide insights into the genetic determinants of kidney function and its decline in a Taiwanese population.
PMID:
43003399
Bibliographic data and abstract were imported from PubMed on 10 Nov 2026.
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