Blood cell aggregation as a hemorheological marker of long-term clinical outcome after percutaneous coronary intervention in patients with coronary artery disease.

Authors

Spartak Lekveishvili, Vera Kapetivadze, Nana Momtselidze, Giorgi Kuchava, Maka Maia Mantskava

Published in

Clinical hemorheology and microcirculation. Pages 13860291261502270. Nov 10, 2026. Epub Nov 10, 2026.

Abstract

BackgroundWe evaluated serial blood cell aggregation changes after PCI in CAD patients and their 12-month outcomes.MethodsWe prospectively enrolled 120 elective PCI CAD patients and 50 frequency-matched controls. Blood was collected pre-PCI, on Days 3, 8, and Month 3. Erythrocyte aggregation index (EAI) was assessed by TAS-plus aggregometry. Patients were grouped into Group I (favorable, n = 106) and Group II (repeat PCI, n = 14).ResultsCAD patients showed higher baseline EAI (0.43 ± 0.06vs.0.29 ± 0.04, p < 0.001), fibrinogen (4.1 ± 0.6vs.2.9 ± 0.4 g/L, p < 0.001), and leukocyte aggregation (32.4 ± 5.8%vs.21.4 ± 4.2%, p < 0.001) than controls. Linear mixed-effects modeling revealed a significant group-by-time interaction for EAI (F(3, 354) = 5.12, p = 0.002). Over 3 months, Group I showed progressive EAI normalization (0.42 ± 0.05 to 0.31 ± 0.03, p < 0.001), whereas Group II maintained elevated EAI (0.46 ± 0.07 to 0.44 ± 0.06, p = 0.245). Leukocyte aggregation increased transiently at Day 3 in both CAD groups (39.8 ± 6.7%vs.40.1 ± 6.5%) and returned to baseline by Month 3 (31.8 ± 5.4% vs. 32.1 ± 5.5%, p = 0.842), showing no persistent between-group differences in this cohort. ADP-induced platelet aggregation was significantly suppressed post-PCI at Day 3 (50.2 ± 7.6%vs.50.7 ± 7.4%, p < 0.001) without between-group differences.ConclusionsPersistent erythrocyte hyperaggregation post-PCI is associated with recurrent ischemia and repeat revascularization and may represent a potential biomarker for clinical risk stratification, pending validation in larger, multicenter prospective studies.

PMID:
43006715
Bibliographic data and abstract were imported from PubMed on 10 Nov 2026.

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