Glandular Tissue Component at Preoperative Breast US and Recurrence Risk in Invasive Breast Cancer.

Authors

Tingting Deng, Woo Kyung Moon, Cuiju Yan, Huiling Xiang, Jun Tang, Fei Xu, Myoung-Jin Jang, Eun Kyung Park, Heera Yoen, Meesun Lee, Sung Ui Shin, Eun Jae Lee, Na Hye Han, Kyung-Hun Lee, Hyeong-Gon Moon, Su Min Ha, Xi Lin

Published in

Radiology. Volume 321. Issue 2. Pages e260681.

Abstract

Background Glandular tissue component (GTC) at breast US is associated with breast cancer risk, but recurrence risk remains unclear. Purpose To evaluate the association between GTC assessed at preoperative breast US and recurrence risk in invasive breast cancer across two tertiary institutions in Korea and China. Materials and Methods This retrospective longitudinal study included consecutive women with invasive breast cancer who underwent surgery between January 2013 and December 2018 in Korea and between January 2013 and December 2019 in China. GTC was qualitatively classified as low (minimal or mild) or high (moderate or marked) on preoperative bilateral US images. GTC was prospectively assessed during routine clinical care at institution A (Korea) and retrospectively assessed using archived images at institution B (China). Competing-risk multivariable Fine-Gray models evaluated GTC as the independent variable for recurrence, with adjustment for clinicopathologic variables. Results Mean age was 52.4 years ± 10.8 (SD) at institution A (n = 5167) and 49.2 years ± 10.1 at institution B (n = 3719). Median interval from surgery to recurrence diagnosis or last follow-up was 6.8 years (IQR, 5.42-8.41 years) at institution A and 8.0 years (IQR, 6.38-9.60 years) at institution B. Ipsilateral or contralateral breast cancer occurred in 145 (2.8%) and 85 patients (2.3%) at institutions A and B, respectively, while regional or distant recurrence occurred in 233 (4.5%) and 520 (14.0%). In multivariable analyses, high GTC was independently associated with increased risk of ipsilateral or contralateral breast cancer at institution A (subdistribution hazard ratio [HR], 1.93; P < .001) and institution B (HR, 2.02; P = .002). There was no evidence of an association between GTC and regional or distant recurrence at either institution A (HR, 0.89; P = .46) or institution B (HR, 1.20; P = .06). Conclusion High GTC at preoperative breast US was independently associated with an increased risk of ipsilateral or contralateral breast cancer after invasive breast cancer treatment, consistently across both institutions. © RSNA, 2026 Supplemental material is available for this article.

PMID:
43007083
Bibliographic data and abstract were imported from PubMed on 10 Nov 2026.

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