Authors
Mahdieh Khorashadizadeh, Fatemeh Salmani, Tahmine Tavakoli
Published in
Neurogastroenterology and motility. Volume 38. Issue 11.
Abstract
Functional dyspepsia is a chronic gastrointestinal disorder with uncertain causes, often linked to anxiety and depression, which can worsen symptoms and hinder treatment success. Although psychological therapies and antidepressants have shown some benefit, the role of anti-anxiety medications remains unclear. This study aims to evaluate the effectiveness of buspirone and mirtazapine in reducing symptoms and improving the quality of life for patients with functional dyspepsia.
In a semi experimental study, 71 patients with functional dyspepsia were randomized to receive either buspirone 15 mg, mirtazapine 7.5 mg, or pantoprazole 40 mg once daily for 12 weeks. Outcomes-anxiety severity, dyspepsia symptom score, quality of life, and adverse events-were assessed at baseline and monthly. Efficacy was analyzed by repeated-measures ANOVA and adverse event rates by chi-square tests.
Both buspirone and mirtazapine significantly outperformed pantoprazole alone in reducing anxiety (buspirone vs. control at 3 months, p = 0.01; both active treatments vs. control, p < 0.05) and in alleviating functional dyspepsia symptoms by Week 12 (both vs. control, p < 0.05), with no difference between the two active drugs.
This study suggests that buspirone and mirtazapine are effective in reducing anxiety and improving symptoms in patients with functional dyspepsia. These findings highlight the potential role of anti-anxiety medications in managing both the psychological and gastrointestinal aspects of this disorder.
PMID:
43004923
Bibliographic data and abstract were imported from PubMed on 10 Nov 2026.
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