Hops β-Acids Extract Enhances Toothpaste's Efficacy in Morning Breath Reduction: Insights From Pooled Analyses of In Vivo Studies.

Authors

Hao Ye, Tao He, Samuel St John, Alejandra Muñoz-Bodnar, Eva Schneiderman, Tammy Curtis, Yingkun Jin, Marianne Zsiska

Published in

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995). Volume 47. Issue Suppl 3. Pages 44-51.

Abstract

To assess the effects of toothpaste formulations incorporating hops beta (β)-acids extract (Activ Bio-Cleanser™) in combination with fluoride systems on the reduction of volatile sulfur compounds (VSCs) in morning breath following 4 days of product use.
Two pooled analyses were conducted using participant-level data on seven previously completed, randomized in vivo breath studies evaluating VSCs measured with a halimeter after 4 days usage of stannous fluoride (SnF2) or regular fluoride (sodium fluoride [NaF]) or sodium monofluorophosphate [MFP]) dentifrice formulations with and without hops β-acids. SnF2 formulations had 0.15%, 0.23%, or 0.50% hops β-acids, while regular fluoride formulations had 0.05%, 0.11%, 0.15%, 0.23%, or 0.50% hops β-acids. Participant-level data was required for inclusion. Data were analyzed using analysis of covariance (ANCOVA) to assess pooled mean VSC difference among direct treatment difference comparisons based on final visit values.
Seven studies were analyzed in total. Four included assessments of SnF2 + hops formulations (79 participants) and four included assessments of regular fluoride + hops formulations (67 participants). SnF2 formulations: A clear dose-dependent reduction in VSC levels was demonstrated for SnF2 + hops formulations. Increasing concentrations of hops-0.15%, 0.23%, and 0.50%-in SnF2 formulations led to progressively greater VSC reductions of 27.3%, 34.0%, and 52.4%, respectively, versus the negative control (regular fluoride without hops) (P ≤ 0.0004). There was also a significant reduction in VSC levels for SnF2 + 0.23% hops (P = 0.0002) and SnF2 + 0.50% hops (P < 0.0001) compared to SnF2 without hops. Regular fluoride formulations: A similar trend was seen for regular fluoride + hops formulations, with the addition of 0.11%, 0.15%, 0.23%, and 0.50% hops showing reduced VSC levels by 13.4%, 19.9%, 20.5%, and 43.8%, respectively, versus negative control. Regular fluoride formulas with hops levels at 0.15% or above were statistically significantly different from the negative control (P ≤ 0.0320). The regular fluoride + 0.50% formula had a statistically significantly greater VSC reduction compared to all other regular fluoride + hops formulations (P ≤ 0.0130).
This analysis shows there is a significant morning breath benefit associated with the addition of hops at 0.15% or greater to SnF2 or regular fluoride toothpaste, with higher levels of hops showing a larger benefit.

PMID:
43007037
Bibliographic data and abstract were imported from PubMed on 10 Nov 2026.

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