Authors
Qimeng Wang, Yunfei Hu, Yuling Zhu, Gautham Chelliah, Jing Peng, Emmanuella Osei-Asante, Melissa Sobanko, Brianna Sanchez, David D Ginty, Xin Maizie Zhou, Shan Meltzer
Published in
Proceedings of the National Academy of Sciences of the United States of America. Volume 123. Issue 46. Pages e2623177123. Nov 17, 2026. Epub Nov 10, 2026.
Abstract
The spinal cord integrates diverse somatosensory inputs and executes motor outputs through anatomically and functionally distinct circuits. Here, we employed spatially resolved single-cell transcriptomic profiling of the adult mouse spinal cord to gain insights into the organizational logic of the spinal cord. Our results reveal distinct spatial and laminar distributions of neuronal subtypes, including axial level and sex-specific differences. Many neuronal subtypes exhibit lamina-specific somatic proximities, suggesting potential regionally specific connectivity. Additionally, neuronal subtypes within the dorsal horn exhibit a wide range of predicted cell-cell communication motifs, as assessed by the spatial distribution of neuropeptide- and other ligand-receptor pairs. Finally, we identified several neuronal subtypes with altered transcriptomic states and predicted cell-cell communications in a model of neuropathic pain. This spatially resolved cellular and molecular map of the spinal cord will facilitate the decoding of circuit mechanisms underlying somatosensory and motor functions in health and disease.
PMID:
43008029
Bibliographic data and abstract were imported from PubMed on 11 Nov 2026.
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