Authors
Qinhua Liu, Chengda Zhang, Shuangci Zhang, Xuan Kuang, Rui Kuang
Published in
Mikrochimica acta. Volume 193. Issue 12. Nov 10, 2026. Epub Nov 10, 2026.
Abstract
A novel co-assembled supramolecular hydrogel was successfully developed. Through rational molecular design, sodium lauroyl glutamate (SLG) was engineered not only to act as an H-bonding partner for co-assembly with glutathione (GSH), thereby reinforcing the gel network, but also to provide the crucial assembly driving force via its hydrophobic tail. A specific gel-to-sol transition (i.e., macroscopic collapse of the supramolecular network) could be triggered by L-His, whereas the hydrogel remained stable against other amino acids, enabling chiral recognition. Based on this mechanism, the gel dissolution was innovatively integrated with the o-phenanthroline/Fe²⁺ chromogenic reaction. A two-compartment sensing platform was constructed where the encapsulated o-phenanthroline was released upon L-His-triggered gel dissolution and could diffuse into another compartment to form an orange-red complex with Fe²⁺. Consequently, a seamless transition from naked-eye qualitative screening to UV-Vis spectroscopic quantitative detection (with a linear range of 10-100 mM and a detection limit of 1.33 µM) was achieved. The good accuracy and reliability of the sensor were verified through the analysis of real samples (human urine, milk). This work provides a novel and efficient analytical platform for L-His detection, and the great potential of supramolecular hydrogels in intelligent sensing systems is demonstrated.
PMID:
43007461
Bibliographic data and abstract were imported from PubMed on 11 Nov 2026.
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