[Retroperitoneal fibrosis (Ormond's disease)].

Authors

Roman Herout, Alexander Kleymann

Published in

Urologie (Heidelberg, Germany). Nov 10, 2026. Epub Nov 10, 2026.

Abstract

Inflammatory progressive retroperitoneal fibrosis (RPF) is characterized by proliferation of soft tissue within the retroperitoneal space. It surrounds the abdominal aorta, iliac vessels and ureters, frequently leading to hydronephrosis. Retroperitoneal fibrosis is classified into primary idiopathic, secondary and immunoglobulin G4 (IgG4)-associated forms. The diagnosis of idiopathic RPF requires exclusion of secondary etiologies and assessment of the lesions in the context of IgG4-associated diseases. The histological confirmation of a retroperitoneal lesion provides additional certainty. Systemic glucocorticoids constitute the gold standard of medical treatment. Furthermore, immunosuppressive agents or tamoxifen can be used. Treatment with the newly approved inebilizumab is a novel approach for the IgG4-associated form. Ureterolysis with intraperitonealization represents the surgical gold standard. Extensively scarred ureters can be reconstructed using e.g., ileal ureter substitution.

PMID:
43007434
Bibliographic data and abstract were imported from PubMed on 11 Nov 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.