Authors
Rafael Duarte, Maria-Estela Moreno Martínez, Antonio Pérez-Martínez, Carlos Solano Vercet, Gemma Gómez, Irene Ambatlle, Rosa Palomino
Published in
Revista clinica espanola. Pages 502656. Nov 10, 2026. Epub Nov 10, 2026.
Abstract
Chronic graft-versus-host disease (cGVHD) is one of the most common complications of allogeneic haematopoietic stem cell transplantation, affecting 30-70% of all patients. The present study was conducted to provide a consensus view of the current management and approach to cGVHD in clinical practice in Spain.
A study with Delphi methodology was carried out involving two rounds of individual assessments by a multidisciplinary panel of 44 experts corresponding to different professional profiles and geographical settings.
In general, heterogeneity was observed between centres in the diagnosis and management of cGVHD, with differences in the process and times of referral or protocol compliance. Although some centres had multidisciplinary teams with reference personnel, there is still room for improvement to establish an optimal and standardized approach. The experts agreed that the creation of a national consensus, as well as continuous training of the professionals, better patient information, and the availability of biomarkers would be key to improving early diagnosis and patient follow-up. With the current treatments, a complete response to therapy is not usually achieved, and a partial response does not always guarantee stability of symptoms. In addition to efficacy, the experts highlighted toxicity reduction, convenience of dosing, and improved quality of life as key factors in choosing treatment. Most of the experts stated that they follow the recommendations of the NIH consensus for the evaluation of response.
PMID:
43009053
Bibliographic data and abstract were imported from PubMed on 11 Nov 2026.
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