Authors
Jiacheng Mi, Huzong Chen, Shanyu Lv, Chaoyan Ou
Published in
Neurotoxicology. Pages 103598. Nov 10, 2026. Epub Nov 10, 2026.
Abstract
Particulate air pollution can decline after emission control or filtration, yet the subsequent course of neurovascular and glial abnormalities remains uncertain. This critical narrative review examines experimental post-exposure reports and human exposure-reduction studies, distinguishing cellular state, direct function, and mechanistic attribution. Experimental findings show different temporal patterns across endothelial inflammatory markers, microglial states, brain metabolism, and behavior. Early blood-brain barrier (BBB) leakage is documented after diesel exhaust, but later normalization of the same function is not established. Some inflammatory measures attenuate after a switch to filtered air, whereas other abnormalities remain detectable weeks or months later. A single late measurement demonstrates an abnormality at that interval rather than its uninterrupted persistence. Human studies report both favorable and null cognitive or developmental outcomes after reduced exposure; these outcomes do not identify cell-specific recovery. Particle composition, exposure route, age, sex, and sampling schedule limit comparison across models. The evidence supports asynchronous post-exposure responses rather than a common sequence of functional restoration. Recovery of a specified neurovascular or glial task requires a documented abnormal phase followed by repeated measurement of that task, while attribution requires separate evaluation of continuing peripheral input.
PMID:
43009026
Bibliographic data and abstract were imported from PubMed on 11 Nov 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 4
- Comments 0