Authors
Simin Yang, Guangbo Li, Xiaoyu Yu
Published in
Clinica chimica acta; international journal of clinical chemistry. Pages 122969. Nov 10, 2026. Epub Nov 10, 2026.
Abstract
Peptides represent promising biomarkers for human diseases, among which mucosa-derived bioactive peptides serve as a vital research source. Nevertheless, their clinical application is largely restricted by low circulating concentrations, high vulnerability to ex-vivo degradation, and the absence of standardized analytical workflows. This review systematically characterizes the fundamental biological properties of mucosa-derived bioactive peptides and comprehensively compares the performance of mainstream quantitative strategies for peptide detection, including immunoassays, mass spectrometry, nanopore-based sensing, and point-of-care testing (POCT). Pre-analytical, analytical, and post-analytical confounding factors that induce measurement bias are critically highlighted. The diagnostic potential of these peptides in digestive, neoplastic, metabolic, and gynecological disorders is summarized. Current major bottlenecks regarding assay standardization, quality control, and clinical translational application are elaborated, and future research directions are proposed to support the analytical and clinical validation of mucosa-derived bioactive peptides for potential diagnostic applications.
PMID:
43009003
Bibliographic data and abstract were imported from PubMed on 11 Nov 2026.
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