[Mitochondrial dysfunction and male reproductive function: Research advances in traditional Chinese and Western medicine].

Authors

Huiying Wu, Jingwen Fu, Wenliang Yao, Shenghui Chen

Published in

Zhonghua nan ke xue = National journal of andrology. Volume 32. Issue 4. Pages 357-361.

Abstract

Mitochondria, as central organelles governing cellular energy metabolism and redox homeostasis, play pivotal roles in spermatogenesis, sperm maturation, and fertilization within the male reproductive system. Emerging evidence indicates that mitochondrial dysfunction including metabolic abnormalities, reactive oxygen species imbalance and dysregulated mitophagy serves as a critical pathological mechanism underlying andrological disorders, particularly male infertility. This review systematically delineates the multifaceted regulatory functions of mitochondria in spermatogenesis and fertilization while exploring their associations with male reproductive function. Furthermore, it synthesizes recent advances in understanding mitochondrial dysfunction-related mechanisms in male infertility from the perspectives of traditional Chinese and Western medicine.

PMID:
43012222
Bibliographic data and abstract were imported from PubMed on 11 Nov 2026.

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