[Endoplasmic reticulum stress in testis-related reproductive dysfunction: A literature review].

Authors

Pengfei Liu, Junjie Wu, Xuejun Shang

Published in

Zhonghua nan ke xue = National journal of andrology. Volume 32. Issue 7. Pages 645-650.

Abstract

Endoplasmic reticulum stress (ERS) is an adaptive response of cells to disruptions in intracellular homeostasis. Moderate ERS maintains intracellular homeostasis by activating unfolded protein responses, whereas prolonged or excessive ERS can trigger apoptotic pathways. Recent studies have highlighted the critical role of ERS in the pathogenesis of testicular reproductive disorders. Multiple factors including varicocele, obesity, diabetes and exposure to environmental toxicants, can induce ERS in the testes, disrupting testicular structural and functional integrity as well as spermatogenesis, and ultimately resulting in male reproductive dysfunction. This review summarizes the molecular regulatory mechanisms of ERS and its involvement in testis-related reproductive dysfunction, aiming to provide a theoretical basis and identify potential therapeutic targets for the prevention and treatment of male infertility.

PMID:
43012196
Bibliographic data and abstract were imported from PubMed on 11 Nov 2026.

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