Hiring in life sciences? Share your open positions with our professional community. Read more Close

Advertisement

Evaluating Wearable Electrodermal Activity as a Candidate Digital Biomarker of Occupational Well-Being: Longitudinal Real-World Study.

Created on 12 Nov 2026

Authors

Henna Salonius, Pasi Kytölä, Satu Pakarinen, Anne Mäkikangas, Virpi Liukkonen, Saija Mauno

Published in

JMIR formative research. Volume 10. Pages e104167. Nov 11, 2026. Epub Nov 11, 2026.

Abstract

Wearable physiological sensing and mobile self-report methods offer new opportunities for monitoring occupational well-being in real-world settings. However, interpreting continuous physiological signals in relation to psychological states such as job burnout and work engagement remains challenging, particularly when using deployable systems that rely on proprietary signal processing.
This study examined a proprietary electrodermal activity (EDA)-derived arousal index as a candidate digital biomarker for research on occupational well-being. We examined associations between job burnout, work engagement, and sympathetic activation indexed by a device-derived EDA metric, and assessed whether combining physiological data with mobile-based ecological momentary assessment (mEMA) of valence provides complementary information.
A total of 75 knowledge workers participated, with sufficient paired physiological and mEMA data obtained from 57 participants in wave 1 and 51 in wave 2 (total observations=108). Participants were monitored continuously over 14 consecutive days at 2 time points 6 months apart. Autonomic arousal was operationalized using the device-derived double normalized electrodermal activity (DNE) index obtained from wearable EDA recordings. Valence was assessed using mEMA. Associations between physiological activation, valence, and occupational well-being outcomes were analyzed using generalized least squares models with a compound-symmetry covariance structure to account for repeated observations within participants.
The wearable-derived DNE index showed a clear diurnal pattern, with higher values during daytime and lower values during nighttime. Greater within-nighttime DNE variability was associated with higher burnout (estimate=0.02, 95% CI 0.01-0.03; P<.001) and lower engagement (estimate=-0.03, 95% CI -0.05 to -0.01; P=.009). The daily DNE × valence interaction was also associated with engagement (estimate=-0.35, 95% CI -0.69 to -0.00; P=.047). Removing all DNE and valence variables significantly worsened model fit for both burnout (χ²₁₀=28.5; P=.002) and engagement (χ²₁₀=23.7; P=.009), supporting their combined explanatory value. Model-based profiles further showed that negative valence was associated with higher predicted burnout and lower predicted engagement than positive valence across both high- and low-arousal scenarios, although prediction intervals were wide and partially overlapping. Model comparisons showed that including physiological and mEMA-based variables improved explanatory power.
These findings provide practical evidence that continuous wearable EDA monitoring can be combined with mEMA in naturalistic occupational settings. Associations between the proprietary DNE index, valence, burnout, and work engagement provide preliminary convergent evidence supporting further evaluation of DNE as a candidate digital biomarker in occupational well-being research. Interpretation remains constrained by the proprietary signal-processing pipeline, and this study does not establish construct-specific validity, prospective predictive performance, screening or diagnostic validity, sensitivity to change, or individual-level monitoring usage.

PMID:
43013762
Bibliographic data and abstract were imported from PubMed on 12 Nov 2026.

Read full publication at:
Please sign in to see all details.

Advertisement

Stats

  • Community rating n/a 0 votes
  • Reviewers' rating n/a 0 votes
  • Your rating

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

  • Recommendations n/a n/a positive of 0 vote(s)
  • Views 5
  • Comments 0

Recommended by

  • No recommendations yet.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.

Advertisement