[Breast reconstruction through tissue engineering: Biological principles, state of the art and clinical perspectives].

Authors

L Lantieri

Published in

Annales de chirurgie plastique et esthetique. Volume 71. Issue 6. Pages 753-759.

Abstract

The breast is composed largely of adipose tissue. Post-mastectomy reconstruction therefore amounts, fundamentally, to regenerating a sufficient volume of autologous fatty tissue from biological components the body already possesses in abundance: adipose cells, a supportive extracellular matrix, and a vascular network. These three non-specialized, readily available ingredients form the unifying biological foundation of all breast tissue engineering strategies. This article presents the underlying biological principles, then critically reviews each current approach - bioresorbable tissue engineering chambers, cell-based bioprinting, xenogenic matrices, cadaveric allograft adipose matrix, external negative-pressure expansion, and enriched fat grafting - with a specific focus on clinical development stage and translation barriers.

PMID:
43014857
Bibliographic data and abstract were imported from PubMed on 12 Nov 2026.

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