[Alcoholic Neuropathy].

Authors

Katsumi Kurokawa

Published in

Brain and nerve = Shinkei kenkyu no shinpo. Volume 78. Issue 11. Pages 1193-1199.

Abstract

Alcoholic neuropathy is one of the most common neurological complications observed in patients with alcohol use disorder. Traditionally, its pathogenesis has been debated as being either a direct neurotoxic effect of ethanol or a consequence of nutritional deficiency. However, current evidence suggests that alcoholic neuropathy should be regarded as a spectrum, in which these two mechanisms contribute to varying degrees and converge into a common pathogenic cascade, leading to length-dependent axonal degeneration. Clinical manifestations differ according to the predominant mechanism. Direct neurotoxicity is typically associated with chronic painful small-fiber neuropathy, whereas nutritional deficiency more often causes acute or subacute large-fiber neuropathy with motor involvement and systemic manifestations of vitamin deficiency. Because no disease-specific diagnostic markers exist, diagnosis requires a comprehensive evaluation of drinking history, nutritional status, clinical findings, and electrophysiological studies. Recognition of this integrated pathogenic model may facilitate the individualized diagnosis and management of alcoholic neuropathy.

PMID:
43014724
Bibliographic data and abstract were imported from PubMed on 12 Nov 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.