[Tuberculosis continuum: new definitions and clinical implications].

Authors

Lorenzo Amato, Joyce Rodrigues Bandeira, Onya Opota, Jesica Mazza-Stalder, Benoit Lechartier, Chloé Cantero

Published in

Revue medicale suisse. Volume 22. Issue 983. Pages 1843-1848. Nov 11, 2026.

Abstract

In 2026, tuberculosis remains a major global public health challenge and the deadliest infectious disease in the world. The concept of the tuberculosis continuum is progressively replacing the traditional distinction between latent tuberculosis infection and tuberculosis disease. It describes Mycobacterium tuberculosis infection as a dynamic spectrum that includes incipient and subclinical stages, which may benefit from early diagnosis and treatment. Interferon-Gamma Release Assays remain the reference tests for screening for tuberculosis infection, although their ability to predict progression to disease is limited. The microbiological diagnosis relies on sputum analysis and rapid molecular assays. This review summarizes current knowledge and emerging diagnostic tools.

PMID:
43016218
Bibliographic data and abstract were imported from PubMed on 12 Nov 2026.

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