Diabetes is associated with improved short-term survival in Fournier's Gangrene.

Authors

Aaron Seto, Emma Laquinta, Kamil Malshy, Taylor Braunagel, Richard Glebocki, Borivoj Golijanin, Allegra Rollo, Madeline Cancian

Published in

World journal of urology. Volume 44. Issue 1. Nov 12, 2026. Epub Nov 12, 2026.

Abstract

To evaluate the influence of diabetes mellitus (DM) on short-term and long-term mortality in Fournier's Gangrene (FG) patients following surgical debridement.
We conducted a retrospective cohort study of FG patients who underwent surgical debridement at Miriam Hospital between October 2011 and December 2023. Mortality was assessed at 90 days post-debridement and through March 2025. Associations between covariates and mortality were evaluated using Cox regression analysis.
Among our 199 FG patient cohort (83% male, 81% White, median age 58 [IQR: 48, 66]), 135 (68%) were diabetic, with 11 diagnosed on admission. Within 90 days post-debridement, diabetes (HR: 0.20, 95% CI: 0.05-0.80 p = 0.023) and BMI (HR: 0.93, 95% CI: 0.87-1.00 p = 0.025) were associated with lower mortality. Over the full study period, age (HR: 1.03, 95% CI: 1.01-1.05 p = 0.011) and Charlson Comorbidity Index (CCI) (HR: 1.21, 95% CI: 1.06-1.38 p = 0.004) predicted higher mortality while diabetic status and BMI were no longer significant.
DM and higher BMI were associated with lower 90-day post-debridement mortality in FG patients, whereas longer-term mortality was independently predicted by age and comorbidity burden rather than diabetes. These associations are hypothesis-generating and warrant prospective evaluation.

PMID:
43018769
Bibliographic data and abstract were imported from PubMed on 13 Nov 2026.

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