Cortical interneuron function in autism spectrum condition.

Authors

Jason W Lunden, Madel Durens, Andre W Phillips, Michael W Nestor

Published in

Pediatric research. Volume 85. Issue 2. Pages 146-154. Epub Oct 26, 2018.

Abstract

Cortical interneurons (INs) are a diverse group of neurons that project locally and shape the function of neural networks throughout the brain. Multiple lines of evidence suggest that a proper balance of glutamate and GABA signaling is essential for both the proper function and development of the brain. Dysregulation of this system may lead to neurodevelopmental disorders, including autism spectrum condition (ASC). We evaluate the development and function of INs in rodent and human models and examine how neurodevelopmental dysfunction may produce core symptoms of ASC. Finding common physiological mechanisms that underlie neurodevelopmental disorders may lead to novel pharmacological targets and candidates that could improve the cognitive and emotional symptoms associated with ASC.

PMID:
30367159
Bibliographic data and abstract were imported from PubMed on 13 Nov 2026.

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