PAG--a multipurpose transmembrane adaptor protein.

Authors

M Hrdinka, V Horejsi

Published in

Oncogene. Volume 33. Issue 41. Pages 4881-92. Oct 09, 2014. Epub Nov 11, 2013.

Abstract

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), also known as Csk-binding protein (Cbp), is a ubiquitously expressed transmembrane adaptor protein present in lipid rafts and involved in a number of signaling pathways. It helps recruit cytoplasmic C-terminal Src kinase (Csk) to lipid raft-associated Src kinases, mediates a link to actin cytoskeleton and interacts with several other important cytoplasmic and plasma membrane-associated proteins. In recent years, PAG has been implicated in various aspects of cancer cell biology. Our review covers all so far published data on this interesting protein.

PMID:
24213579
Bibliographic data and abstract were imported from PubMed on 13 Nov 2026.

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