Authors
Efthymios Papadopoulos, Steve Kwon, Divya Mathew, Daniel Sibley, Filipe Coutinho
Published in
Journal of geriatric oncology. Pages 104683. Nov 12, 2026. Epub Nov 12, 2026.
Abstract
The increasing proportion of older adults worldwide has important implications for clinical oncology practice. Although progress has been made in geriatric oncology research, older adults with cancer remain underrepresented in clinical trials, underscoring the need for further research to address their unique treatment considerations and improve their care and support. Given that age alone is insufficient to inform oncologic management, the age-associated changes across organ systems along with geriatric assessment should be considered in treatment decision-making and can inform the need for targeted interventions. This review discusses key age-related changes in the cardiovascular, nervous, musculoskeletal, gastrointestinal, renal, and immune systems, the impact of cancer and its treatment on each system, along with clinical implications for cancer treatment and management strategies for older adults with cancer.
PMID:
43020690
Bibliographic data and abstract were imported from PubMed on 13 Nov 2026.
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