Palladium-Catalyzed Three-Component Dearomative Carbofluoroallylation of Polycyclic Indoles with gem-Difluorocyclopropanes and Ketones.

Authors

Xuexue Zhang, Jie Suo, Yingying Deng, Yuxuan Li, Shuheng Zhang, Zhaodong Li

Published in

Organic letters. Volume 28. Issue 45. Pages 14161-14166. Nov 13, 2026.

Abstract

We herein report a robust palladium-catalyzed, three-component dearomative carbofluoroallylation of polycyclic indoles using gem-difluorocyclopropanes and ketones. This method enables the diversity-oriented synthesis (DOS) of complex ketone-indolines featuring a linear 2-fluoroallylic motif. With its broad substrate scope and high functional group tolerance, the protocol is highly effective for the late-stage functionalization of natural product derivatives. Moreover, the cross-coupling adducts can be readily elaborated into a variety of distinct fluoroallylic scaffolds, demonstrating the significant synthetic utility of this approach.

PMID:
43023908
Bibliographic data and abstract were imported from PubMed on 13 Nov 2026.

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