Mechanistic Characterization of a Multiproduct Sesquiterpene Synthase for Triquinanes and Quadranes from Streptomyces pathocidini.

Authors

Kizerbo A Taizoumbe, Bernd Goldfuss, Jeroen S Dickschat

Published in

Organic letters. Volume 28. Issue 45. Pages 14174-14179. Nov 13, 2026.

Abstract

Through genome mining, a sesquiterpene synthase from Streptomyces pathocidini was discovered and shown to generate a mixture of multiple products. Isotopic labeling experiments and DFT calculations were performed for detailed insight into its complex cyclization mechanism. Enzyme engineering through site-directed mutagenesis gave access to four additional products, one of which occurred as a minor constituent in the wild-type enzyme.

PMID:
43023893
Bibliographic data and abstract were imported from PubMed on 13 Nov 2026.

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