Authors
Fengming Luan, Guofeng Chen, Ke Chen, Chaoyang Zhang, Xiaoman He, Jian Chen, Shenbin Xu
Published in
Frontiers in oncology. Volume 16. Pages 1912517. Epub Oct 30, 2026.
Abstract
COL1A2 encodes type I collagen alpha2 chain, a stromal component in gastric cancer (GC); its prognostic value, cellular origin, and immune microenvironment relation remain unclear.
We analyzed TCGA-STAD, GSE63089, and ACRG GSE62254. Associations between COL1A2 abundance and overall survival (OS), clinicopathology, pathways, and tumor microenvironment were assessed. High/low groups by median expression. Two Cox models used pathological stage or separate T/N/M. Immunotherapy response predicted via TIDE and IPS. WGCNA, PPI, and LASSO with five ECM genes, ten-fold cross-validation and 200 repeats, were applied. qPCR and Western blot measured mRNA and protein in seven paired tissues.
COL1A2 was higher in GC and linked to poorer OS, but time-dependent AUCs were 0.60, 0.65, 0.66. In ACRG, OS association was not significant (HR 1.83, P = 0.085). Per SD increase, adjusted HR was 1.21 (stage model, P = 0.036) and 1.14 (T/N/M model, P = 0.171). C-index gains were only 0.006 and 0.003. Higher abundance correlated with stroma-rich microenvironment and M2 macrophage infiltration. TIDE/IPS predicted lower ICI response probability. LASSO selected SPARC, ELN, and BGN stably. Tumor tissues showed higher mRNA and protein.
COL1A2 associates with poor prognosis, stromal remodeling, and predicted immunotherapy response, but its prognostic effect varies between models and discrimination improvement is small.
PMID:
43031651
Bibliographic data and abstract were imported from PubMed on 14 Nov 2026.
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