The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.

Authors

Janjira Soh, Shivaanishaa Raventhiran, Jasinda H Lee, Zi Xiang Lim, Jorming Goh, Brian K Kennedy, Andrea B Maier

Published in

GeroScience. Oct 18, 2023. Epub Oct 18, 2023.

Abstract

Functional decline of physiological systems during ageing leads to age-related diseases. Dietary glycine increases healthy lifespan in model organisms and might decrease inflammation in humans, suggesting its geroprotective potential. This review summarises the evidence of glycine administration on the characteristics of eleven physiological systems in adult humans. Databases were searched using key search terms: 'glycine', 'adult', 'supplementation'/ 'administration'/ 'ingestion'/ 'treatment'. Glycine was administered to healthy and diseased populations (18 and 34 studies) for up to 14 days and 4 months, respectively. The nervous system demonstrated the most positive effects, including improved psychiatric symptoms from longer-term glycine administration in psychiatric populations. While longer-term glycine administration improved sleep in healthy populations, these studies had small sample sizes with a high risk of bias. Larger and long-term studies with more robust study designs in healthy populations to examine the effects of glycine administration on preventing, delaying or reversing the ageing process are warranted.

PMID:
37851316
Bibliographic data and abstract were imported from PubMed on 18 Oct 2023.

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