Preprints

Created 25 Sep 2026

Deciphering Mechanistic Signatures in Drug-Drug Interactions with Dual Topology Graphs

by Ma, W., Bi, X., Jiang, H., Lu, W., Nie, J., Lin, S., Lin, J., Wei, Z., Zhang, H., Zhang, S.

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Created 02 Oct 2026

Synthesis of substituted oxabicyclic phenol derivatives with increased affinity and activity for the classical estrogen receptor ERα

by Pepermans, R. A., Tenorio, A. J., Saxon, T., Talipov, M. R., Maio, W. A., Ramesh, C., Prossnitz, E. R., Arterburn, J. B.

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Created 26 Sep 2026

Physiological Aging and Cardiovascular Disease Distinctly Remodel the Human Cardiac Lymphatic Endothelium

by Chen, H., Chao, S., Shi, Y., Yang, Z., Roh, J., Yu, P. B., Xia, P.

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Created 01 Oct 2026

Chronic Social Isolation Reshapes the Metabolome in Drosophila

by Migliaccio, D., Spicer, C., Nguyen, A. D., Vora, A., Zhang, Z., Li, W.

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Created 30 Sep 2026

Macrophage-derived IL-27 sustains autoreactive CD8+ cytotoxic T cells in autoimmune hepatitis

by Hao, K., Baptista, S. G., Beaumond, A. S. V., Schafer, D. M., Kaja, P. L., Chiang, K., Gao, K. M., Nundel, K., Kumar, S. V., Sherman, M. S., Marshak-Rothstein, A., Varanasi, S. K.

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Created 24 Sep 2026

Dynamic microtubule-end structure governs multivalent kinetochore coupling by the Dam1c ring

by Kalutskii, M., Grubmueller, H., Igaev, M.

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Created 29 Sep 2026

A regulatory T cell signature provides a shared molecular basis for the therapeutic window of opportunity in rheumatic disease

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Created 25 Sep 2026

Computer-Assisted Systematic Chemical-Space Mapping of a First-in-Class Peripherally Restricted α2AAR Agonist through Scaffold-Seeded Enumeration

by Moore, C., Zhu, L., Cheng, Z.

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Created 29 Sep 2026

Seasonal population structure and adaptive signatures across long-term marine microbial time series

by Huang, T.-C., Latorre, F., Krabberod, A. K., Gonzalez-Motos, S., Balague, V., Gasol, J. M., Galand, P. E., Logares, R.

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Created 30 Sep 2026

Robust Induction of Spontaneous Recurrent Seizures and Hippocampal Sclerosis with Synthetic Kainic Acid in the Intrahippocampal Kainate Model

by Grillo, A. R., O'Gorman, P., Krummradt, M., Kenny, M., Staley, K. J., Lillis, K. P., Lau, L. A.

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